REACTION OF N-(AMINOAMIDINO)THIOUREA DERIVATIVES WITH DIMETHYLACETYLENE DICARBOXYLATE


Tezin Türü: Yüksek Lisans

Tezin Yürütüldüğü Kurum: Erciyes Üniversitesi, Fen Fakültesi, Kimya, Türkiye

Tezin Onay Tarihi: 2018

Tezin Dili: İngilizce

Öğrenci: IHAB ADNAN SALMAN AL-JANABI

Asıl Danışman (Eş Danışmanlı Tezler İçin): Şaban Patat

Eş Danışman: EMİN SARIPINAR

Özet:

Dimethyl acetylenedicarboxylate (DMAD) has been used in numerous heterocyclic

arrangements and considered as an essential building in a natural union. In this work, a

short and productive one-pot reaction of 4-isothiazolidine-5-ylidene acetic acid

derivation is described. A green and effective technique for the a mixture of more up to

date 4-isothiazolidine-5-ylidene acetic acid derivation (IHB 1-16, yield 38-85%)N-

(arylideneamino)-N-(arylthiocarbamyl) guanidine (AGII 1- 22) with

diethylacetyylenedicarboxylate has been created in methanol by refluxing. We would

like to investigate the synthesis of thiazoline compounds from thiocarbamoyl guanidines

derivatives possessing N-H groups and S=C bond which react with DMAD to give

highly functionalized 4- oxothiazolidin-5-ylidene acetate derivatives. In this reaction,

both sulfur group and amino group are capable to react with DMAD. It was found that

thiourea react with DMAD exclusively with sulfur atom. The structure of the new

compounds was established by IR and NMR spectroscopy