Guaianolides from Chrysophthalmum montanum (DC.) Boiss


GÜRBÜZ P., DOĞAN Ş. D., PAŞAYEVA L., DOKUMACI A. H., Eroğlu D., Paksoy M. Y., ...More

1st International Conference on Natural Products for Cancer Prevention and Therapy, İstanbul, Turkey, 31 August - 02 September 2015, pp.32

  • Publication Type: Conference Paper / Full Text
  • City: İstanbul
  • Country: Turkey
  • Page Numbers: pp.32
  • Erciyes University Affiliated: Yes

Abstract

The small genus Chrysophthalmum (tribe Inuleae) with four species, distributed over South-East Türkiye and Iran. While the chemistry of many genera of Inuleae group has been studied nothing is known about that of Chrysophthalmum. Different types of sesquiterpene lactones; guaianolides, eudesmanolides, germacranes, pseudo-guaianolides have been reported from Inula species which is the most close genus to Chrysophytalmum. Noteworthy, some of these sesquiterpene lactones showed cytotoxic, antibacterial, immunmodulatory and anti-inflammatory activities. In the course of a search for cytotoxic sesquiterpenes in the Asteraceae, we have examined C. montanum a plant on which extensive phytochemical studies have not been previously conducted and isolated four new [2-O-β-D-glucopyranoside-4α- hydroxy-guai-1(10)-en-12-8β-olide (1), 2-O-(6′-trans-caffeoyl)-β-D-glucopyranoside-4α-hydroxy-guai-1(10)-en-12-8β- olide (2), 4-O-β-D-glucopyra-noside-10β-hydroxy-guai-1 (2)-en-12-8β-olide (3) and 4-O-β-D-glucopyranoside-10β- hydroxy-guai-12-8β-olide (4)] and three known [2-Deoxypleniradin, 2-Deoxy-6-acetoxy-pleniradin, 4β, 10α- Dihydroxy-5αH-guai-1(2), 11(13)-dien-12,8α-olide] guaianolide type sesquiterpene lactones, along with the three methoxylated flavonoids and chlorogenic acid. The structures of these compounds were elucidated using spectroscopic methods (UV, IR, 1H-NMR, 13C-NMR, 2D-NMR and MS). We would like to thank TUBITAK (Grant No: 112S553) and Research foundation of Erciyes University (TCD-2012-4006) for financially supporting this project.