The influence of obesity on ICSI outcomes in women with polycystic ovary syndrome


Özgün M. T. , ULUDAĞ S. Z. , ÖNER G., Batukan C., Aygen E. M. , Şahin Y.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY, vol.31, no.3, pp.245-249, 2011 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 3
  • Publication Date: 2011
  • Doi Number: 10.3109/01443615.2010.546906
  • Title of Journal : JOURNAL OF OBSTETRICS AND GYNAECOLOGY
  • Page Numbers: pp.245-249

Abstract

The objective of the study was to compare intracytoplasmic sperm injection (ICSI) outcome and gonadotropin doses between obese women with PCOS and non-obese patients with PCOS. This follow-up study represents ICSI outcomes in obese women with PCOS (BMI >= 30 kg/m(2)) compared with non-obese women with PCOS (BMI < 30 kg/m(2)). Obese (n=18) and non-obese (n=26) women with PCOS underwent long protocol pituitary suppression, ovarian stimulation and ICSI with fresh embryo transfer. Obese patients with PCOS required higher doses of gonadotropin (2994 IU vs 1719 IU; p < 0.001). Miscarriage rate was significantly higher in obese women compared with the non-obese women with PCOS (60% vs 6.7%, p=0.002). Our results are valuable for counselling couples before initiation of assisted reproduction techniques (ART).