5,10-Methylenetetrahydrofolate reductase C677T gene polymorphism in Behcet's patients with or without ocular involvement


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Ozkul Y. , Evereklioglu C. , Borlu M. , Taheri S. , Calis M. , Dundar M. , ...More

BRITISH JOURNAL OF OPHTHALMOLOGY, vol.89, no.12, pp.1634-1637, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 89 Issue: 12
  • Publication Date: 2005
  • Doi Number: 10.1136/bjo.2005.076836
  • Title of Journal : BRITISH JOURNAL OF OPHTHALMOLOGY
  • Page Numbers: pp.1634-1637

Abstract

Background: Increased serum levels of homocysteine (Hcy) have been reported in patients with Behcet's disease ( BD) with an established risk factor for vascular involvement. Recently, the authors demonstrated that elevated Hcy levels are associated with ocular involvement in such patients. On the other hand, elevated levels of Hcy can result from genetic errors. Indeed, a mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR C677T) gene influences Hcy metabolism and, therefore, MTHFR C677T polymorphism provokes hyperhomocysteinaemia.