BRITISH JOURNAL OF OPHTHALMOLOGY, cilt.89, ss.1634-1637, 2005 (SCI İndekslerine Giren Dergi)
Background: Increased serum levels of homocysteine (Hcy) have been reported in patients with Behcet's disease ( BD) with an established risk factor for vascular involvement. Recently, the authors demonstrated that elevated Hcy levels are associated with ocular involvement in such patients. On the other hand, elevated levels of Hcy can result from genetic errors. Indeed, a mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR C677T) gene influences Hcy metabolism and, therefore, MTHFR C677T polymorphism provokes hyperhomocysteinaemia.