Indomethacin prevents TGF-β-induced epithelial-to-mesenchymal transition in pancreatic cancer cells; evidence by Raman spectroscopy

Sezer G., Önses M. S., Şakir M., Şahin F., Çamdal A., Sezer Z., ...More

SPECTROCHIMICA ACTA - PART A: MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, vol.280, pp.1-9, 2022 (SCI-Expanded)

  • Publication Type: Article / Article
  • Volume: 280
  • Publication Date: 2022
  • Journal Name: SPECTROCHIMICA ACTA - PART A: MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, Chimica, Compendex, EMBASE, INSPEC, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.1-9
  • Erciyes University Affiliated: Yes

Abstract

Pancreatic ductal adenocarcinoma (PDAC) has a very low survival rate due to the late detection and poor

response to chemotherapy. Epithelial-to-mesenchymal transition (EMT) is considered an important step in tumor

progression with regard to invasion and metastasis, and Transforming Growth Factor-beta (TGF-β) signaling has

been shown to play an important role in EMT. Therefore, we aimed to investigate whether indomethacin, an anti-

inflammatory and analgesic drug, has any effect on TGF-β-induced EMT in pancreatic cancer cell line and analyze

the changes in their molecular structures by Raman spectroscopy and other molecular techniques..............