Indomethacin prevents TGF-β-induced epithelial-to-mesenchymal transition in pancreatic cancer cells; evidence by Raman spectroscopy
SPECTROCHIMICA ACTA - PART A: MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, vol.280, pp.1-9, 2022 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 280
- Publication Date: 2022
- Journal Name: SPECTROCHIMICA ACTA - PART A: MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, Chimica, Compendex, EMBASE, INSPEC, MEDLINE, Veterinary Science Database
- Page Numbers: pp.1-9
- Erciyes University Affiliated: Yes
Abstract
Pancreatic ductal adenocarcinoma (PDAC) has a very low survival rate due to the late detection and poor
response to chemotherapy. Epithelial-to-mesenchymal transition (EMT) is considered an important step in tumor
progression with regard to invasion and metastasis, and Transforming Growth Factor-beta (TGF-β) signaling has
been shown to play an important role in EMT. Therefore, we aimed to investigate whether indomethacin, an anti-
inflammatory and analgesic drug, has any effect on TGF-β-induced EMT in pancreatic cancer cell line and analyze
the changes in their molecular structures by Raman spectroscopy and other molecular techniques..............