Synthesis and antibacterial activity of new hydrazide-hydrazones derived from Benzocaine


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Han M. I. , Gurol G., Yildirim T., Kalayci S., Sahin F., Kucukguzel S. G.

MARMARA PHARMACEUTICAL JOURNAL, vol.21, no.4, pp.961-966, 2017 (Journal Indexed in ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 4
  • Publication Date: 2017
  • Doi Number: 10.12991/mpj.2017.34
  • Title of Journal : MARMARA PHARMACEUTICAL JOURNAL
  • Page Numbers: pp.961-966

Abstract

A novel series of new eleven benzocaine hydrazide derivatives, N-(4-{[2-(nonsubstituted/ substitutedfuryl/ phenyl/ pyridinyl/ thienyl/ pyrrole) methylidene]hydrazinyl] carbonyl} phenyl) benzamides [3a-k] have been synthesized in this study. The structures of the new compounds were determined by spectral (FT-IR and H-1-NMR) methods and their purity was proven by elemental analysis and thin layer chromatography. These compounds were evaluated for in vitro antibacterial activity by using micro-well dilution method against Escherichia coli ATCC 10536, Escherichia coli ATCC 15442, Staphylococcus aureus ATCC 6538, Pseudomonas aeruginosa ATCC 15442, Acinetobacter baumannii, Klebsiella pneumonia ATCC 13883.