This study aimed to evaluate the effectiveness of ivermectin on the treatment of bovine cutaneous papillomatosis. Twenty-four Holstein calves between 9 and 17 months of age with cutaneous papillomatosis were placed into three groups with six in group I, and nine in groups II and III. Group I served as a control group and received no treatment. Ivermectin at a dose of 0.2 mg/kg was administered subcutaneously as a single dose to the animals in Group II and twice with 15 days intervals to animals in Group III. The first ivermectin application was considered as the 0th day Animals were monitored at 15 days intervals up to 3 months. No remission was observed in the control group (Group I). In Group II eight out of nine animals (88.8%,) and in Group III seven out of nine animals (77.7%) showed complete recovery within 3 month observation period. It was concluded that ivermectin, as either single or double dose applications, is effective as a treatment for cutaneous papillomatosis. (C) 2007 Elsevier Ltd. All rights reserved.