Aim: In this study, it was aimed to reveal a more effective model depending on the
dose and time by evaluating histopathological properties and biochemical parameters, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST),
albumin, triglyceride, cholesterol in carbon tetrachloride and thioacetamide (CCl4
Method: Rats were divided into three groups for each model and intraperitoneally
(i.p.) injected with CCl4
(0.5 ml/kg, 1.0 ml/kg, 2.0 ml/kg) and TAA (100 mg/kg, 200 mg/
kg, 300 mg/kg) for 4, 6 and 8 weeks, three times weekly, respectively.
Results: In the biochemical investigation, ALT and AST values in the only 0,5 ml
CCL4 of groups for 6 and 8 weeks and were found to have significant differences
compared to the control groups (p <0.05), while the other biochemicals parameters
values did not reveal significant difference in the groups (p >0.05). According to the
results of the histopathology in the liver tissues, both the control groups showed a
normal histological feature. The hepatofibrotic alterations were remarkable in the
and TAA models fibrosis depending on the increasing dose and time in all of
Conclusion: Our results showed that the dose and time were reached up to until
the cirrhosis for eighth week. These results would be a helpful reference for hepatofibrotic studies.