The aim of this study to present the cytogenetic approach in a case of uveodermatologic syndrome in a 18-months-old, male, Siberian Husky. This dog was referred with a history of vision impairment and bilateral redish eyes. Clinical examination confirmed depigmentation over the lips and mouth mucosal area. On ophthalmic examination there was bilateral dilated pupilla, depigmentation of the fundus with visionable choroidal vessels, posterior uveitis, and loss of vision. A presumptive diagnosis of uveodermatological syndrome was made. Complete blood counts and biochemical parameters were normal. The case was cytogenetically evaluated, and GTG (G-bands by trypsin using Giemsa)-banding was performed. No numerical chromosomal anomalies were found. Medical treatment consisted in oral and topical administration of dexamethazone, with 1% syclopantholathydroclorur eye drop. To depressed immune reaction azathioprine also given by oral route. Dermatologic signs showed good improvement but the dog remained blind.