Pentraxin 3 as a novel bio-marker of inflammation and endothelial dysfunction in autosomal dominant polycystic kidney disease

Kocyigit I., Eroğlu E., Orscelik O., Ünal A., Gungor O., Ozturk F., ...More

JOURNAL OF NEPHROLOGY, vol.27, no.2, pp.181-186, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.1007/s40620-014-0045-4
  • Journal Name: JOURNAL OF NEPHROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.181-186
  • Keywords: Polycystic kidney disease, Pentraxin-3, Endothelial dysfunction, CORONARY-HEART-DISEASE, C-REACTIVE PROTEIN, CARDIOVASCULAR-DISEASE, HEMODIALYSIS-PATIENTS, RENAL-FUNCTION, ASSOCIATIONS, RESISTANCE, MORTALITY, RISK, PTX3
  • Erciyes University Affiliated: Yes

Abstract

Cardiovascular disease (CVD) is the main cause of mortality in patients with autosomal dominant polycystic kidney disease (ADPKD). Prior to hypertension early vascular changes and inflammation have been reported. We aimed to investigate long pentraxin 3 (PTX-3), which has been recently described as a biomarker of inflammation, and its relation with endothelial dysfunction in early ADPKD patients.