The ototoxic effect of intratympanic terbinafine applied in the middle ear of rats


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Sagit M. , Somdas M. A. , KORKMAZ F., AKCADAG A.

JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, vol.42, 2013 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 42
  • Publication Date: 2013
  • Doi Number: 10.1186/1916-0216-42-13
  • Title of Journal : JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY

Abstract

Background: Otomycosis is defined as an infection of the external ear canal with fungal agents. The treatment of the disease is cleansing and drying of the external ear canal, identification and treatment of any predisposing factors and application of topical antifungal agents. Terbinafine is used as an antifungal agent to treat otomycosis. We proposed to investigate the probable ototoxic effect of terbinafine solution on auditory brain stem response (ABR) and distortion product otoacoustic emission (DPOAE) when applied intratympanically in the middle ear of rats.