Age-dependent decreases in mitogen-stimulation level and RNA content in peripheral blood mononuclear cells of down syndrome patients

Hamurcu, ZÜHAL; Demirtas, Halil; Patiroglu, TÜRKAN; Kumandas, SEFER; IMAMOGLU, NEFİSE; OZKU, Yusuf; DONMEZ-ALTUNTAS, HAMİYET

doi:10.1002/cyto.b.20139

Age-dependent decreases in mitogen-stimulation level and RNA content in peripheral blood mononuclear cells of down syndrome patients

Hamurcu Z., Demirtas H., Patiroglu T., Kumandas S., IMAMOGLU N. N., OZKU Y., ...Daha Fazla

CYTOMETRY PART B-CLINICAL CYTOMETRY, sa.1, ss.43-48, 2007 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: Sayı: 1
Basım Tarihi: 2007
Doi Numarası: 10.1002/cyto.b.20139
Dergi Adı: CYTOMETRY PART B-CLINICAL CYTOMETRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.43-48
Anahtar Kelimeler: down syndrome, trisomy 21, NORs, RNA content, aging, flow cytometry
Erciyes Üniversitesi Adresli: Evet

Özet

Objective: The aim of the present study was to determine whether or not the phytohemagglutinin (PHA)-activated proliferation and average RNA content in peripheral blood mononuclear cells (PBMC) of Down syndrome (DS) patients change with age.