Akademik Veri Yönetim Sistemi
Electrochimica Acta, cilt.553, 2026 (SCI-Expanded, Scopus)
A novel electrochemical sensor based on a ZnAlZr–LTH@ZnTiO₃ nanocomposite–modified glassy carbon electrode (GCE) was developed for the first time for the sensitive determination of belumosudil (BLM). The synergistic combination of layered triple hydroxide with ZnTiO₃ nanoparticles enhanced the electroactive surface area, conductivity, and electron-transfer kinetics of the electrode, as confirmed by cyclic voltammetry and electrochemical impedance spectroscopy. Using differential pulse voltammetry under optimized conditions (0.1 M Britton–Robinson buffer, pH 2.0), BLM exhibited a well-defined anodic peak at approximately 0.8 V. The sensor showed excellent linearity over the concentration range of 0.05–1.1 µM (R² = 0.997), with a limit of detection of 1.53 nM and a limit of quantification of 5.1 nM. The method demonstrated high selectivity, repeatability, and reproducibility, and was successfully applied to the determination of BLM in human serum, urine, and pharmaceutical tablet samples with satisfactory recoveries. The greenness of the proposed method was evaluated using the Greenness Evaluation Metric for Analytical Methods (GEMAM), yielding a total score of 5.921 and confirming its environmentally friendly nature. Overall, the ZnAlZr–LTH@ZnTiO₃/GCE provides a simple, cost-effective, highly sensitive, and sustainable electrochemical platform for BLM analysis in complex matrices.