5 TH INTERNATIONAL BAŞKENT CONGRESS ON PHYSICAL, SOCIAL AND HEALTH SCIENCES, Ankara, Turkey, 11 - 12 June 2022, pp.567
In this study, malondialdehyde (MDA), an indicator of oxidative stress, and superoxide dismutase (SOD) and glutathione (GSH) levels, which are antioxidants, were determined in kidney tissues of rats treated with different doses of zinc oxide nanoparticles (ZnONP). Forty male (200-250 g) Wistar albino rats were divided into 5 groups of 8 each. The first group (control) was given 0.5 ml of physiological saline; II. group, 5 mg/kg (b.w.) ZnO; III. group, 10 mg/kg (b.w.) ZnO; IV. group, 5 mg/kg (b.w.) ZnONP and group V. 10 mg/kg (b.w.) ZnONP intraperitoneally (i.p.) were administered every other day for 14 days. At the end of the study, MDA, SOD and GSH levels were determined in kidney tissues obtained from rats. In terms of kidney MDA levels, there was no statistical difference between the control group
and the 5 and 10 mg/kg ZnO groups. The MDA levels of the 5 mg/kg ZnONP group were not different from the group given the same amount of ZnO, but showed a significant increase compared to the control group. The MDA levels of the 10 mg/kg ZnONP group were found to be significantly higher than both the control and 10 mg/kg ZnO groups. Compared to the control group, kidney SOD and GSH levels in all other groups showed a statistically insignificant decrease. As a result, in this study, it was found that ZnONP could increase the oxidation level; although it is thought that it may have a reducing effect on antioxidant levels, it was concluded that more detailed studies should be done.