The effects of agomelatine on cognitive functions and neurogenesis in male and female rats subjected to acute stress
Neurophysiology, cilt.57, sa.3-4, ss.127-138, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 57 Sayı: 3-4
- Basım Tarihi: 2025
- Doi Numarası: 10.1007/s11062-026-10006-4
- Dergi Adı: Neurophysiology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE
- Sayfa Sayıları: ss.127-138
- Anahtar Kelimeler: Acute stress, Agomelatine, Cortisol, Hippocampus, Neurogenesis, Sex difference, Y‑maze
- Erciyes Üniversitesi Adresli: Evet
Özet
Agomelatine is a melatonergic antidepressant that has been shown to exert beneficial effects on stress-related behavioral and neurobiological outcomes. The present study investigated its impact on cognitive functions and neurogenesis in rats given acute stress. Male and female rats (n = 10 per group) were divided into four subgroups: control, acute stress, agomelatine-treated control, and agomelatine-treated stress. Agomelatine (10 mg/kg/day) was supplied via gavage for 14 days. Behavioral assays (sucrose preference, forced swimming test, Y‑maze) and immunohistochemical analyses (DCX, Nestin, Ki-67) were conducted. Agomelatine treatment improved cognitive function in stressed rats, reduced cortisol levels, and increased markers of hippocampal neurogenesis. These data demonstrate that agomelatine mitigates acute stress-induced behavioral and neuroendocrine changes, suggesting its potential function in stress-related disease.