Intraperitoneal Administration of Low Dose Aluminium in The Rat: How Good is It to Produce a Model for Alzheimer Disease

ULUSOY H. B., SONMEZ M. F., KILIÇ E., CALISKAN K., KARACA B., KARA M., ...Daha Fazla

ARCHIVES ITALIENNES DE BIOLOGIE, cilt.153, sa.4, ss.266-278, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 153 Sayı: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.12871/00039829201543
  • Dergi Adı: ARCHIVES ITALIENNES DE BIOLOGIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.266-278
  • Anahtar Kelimeler: Alzheimer Disease, Aluminium, Long-term Potentiation, Immunohistochemistry, Oxidative Stress, LONG-TERM POTENTIATION, OXIDATIVE STRESS, BRAIN ALUMINUM, WATER-MAZE, RISK, ABSORPTION, GENERATION, EXPOSURE, AREAS, BONE
  • Erciyes Üniversitesi Adresli: Evet

Özet

Since neurooxicity of aluminium (Al) resembles the progressive neurodegeneration observed in Alzheimer Disease (AD), Al administration in several ways has been used to produce AD model. Intraperitoneal (ip) low dose (4.2 mg/kg) Al injection in rats for long periods is the preferred method by some researchers. In this paper, the efficiency of this method for producing an AD model was evaluated.