Intraperitoneal Administration of Low Dose Aluminium in The Rat: How Good is It to Produce a Model for Alzheimer Disease

ULUSOY H. B., SONMEZ M. F., KILIÇ E., CALISKAN K., KARACA B., KARA M., ...More

ARCHIVES ITALIENNES DE BIOLOGIE, vol.153, no.4, pp.266-278, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 153 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.12871/00039829201543
  • Journal Name: ARCHIVES ITALIENNES DE BIOLOGIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.266-278
  • Keywords: Alzheimer Disease, Aluminium, Long-term Potentiation, Immunohistochemistry, Oxidative Stress, LONG-TERM POTENTIATION, OXIDATIVE STRESS, BRAIN ALUMINUM, WATER-MAZE, RISK, ABSORPTION, GENERATION, EXPOSURE, AREAS, BONE
  • Erciyes University Affiliated: Yes

Abstract

Since neurooxicity of aluminium (Al) resembles the progressive neurodegeneration observed in Alzheimer Disease (AD), Al administration in several ways has been used to produce AD model. Intraperitoneal (ip) low dose (4.2 mg/kg) Al injection in rats for long periods is the preferred method by some researchers. In this paper, the efficiency of this method for producing an AD model was evaluated.