Intraperitoneal Administration of Low Dose Aluminium in The Rat: How Good is It to Produce a Model for Alzheimer Disease


ULUSOY H. B. , SONMEZ M. F. , KILIÇ E. , CALISKAN K., KARACA B., KARA M., ...Daha Fazla

ARCHIVES ITALIENNES DE BIOLOGIE, cilt.153, ss.266-278, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 153 Konu: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.12871/00039829201543
  • Dergi Adı: ARCHIVES ITALIENNES DE BIOLOGIE
  • Sayfa Sayıları: ss.266-278

Özet

Since neurooxicity of aluminium (Al) resembles the progressive neurodegeneration observed in Alzheimer Disease (AD), Al administration in several ways has been used to produce AD model. Intraperitoneal (ip) low dose (4.2 mg/kg) Al injection in rats for long periods is the preferred method by some researchers. In this paper, the efficiency of this method for producing an AD model was evaluated.