Intraperitoneal Administration of Low Dose Aluminium in The Rat: How Good is It to Produce a Model for Alzheimer Disease


ULUSOY H. B. , SONMEZ M. F. , KILIÇ E. , CALISKAN K., KARACA B., KARA M., ...More

ARCHIVES ITALIENNES DE BIOLOGIE, vol.153, no.4, pp.266-278, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 153 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.12871/00039829201543
  • Title of Journal : ARCHIVES ITALIENNES DE BIOLOGIE
  • Page Numbers: pp.266-278

Abstract

Since neurooxicity of aluminium (Al) resembles the progressive neurodegeneration observed in Alzheimer Disease (AD), Al administration in several ways has been used to produce AD model. Intraperitoneal (ip) low dose (4.2 mg/kg) Al injection in rats for long periods is the preferred method by some researchers. In this paper, the efficiency of this method for producing an AD model was evaluated.