Yönez M. K., Tüfekçi E., Alpman U., Ekinci G.
VETERINARY SCIENCES, cilt.12, sa.11, ss.1-18, 2025 (SCI-Expanded, Scopus)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
12
Sayı:
11
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Basım Tarihi:
2025
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Doi Numarası:
10.3390/vetsci12111033
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Dergi Adı:
VETERINARY SCIENCES
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Derginin Tarandığı İndeksler:
Scopus, Science Citation Index Expanded (SCI-EXPANDED), CAB Abstracts, Veterinary Science Database, Directory of Open Access Journals
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Sayfa Sayıları:
ss.1-18
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Açık Arşiv Koleksiyonu:
AVESİS Açık Erişim Koleksiyonu
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Erciyes Üniversitesi Adresli:
Evet
Özet
This study aimed to evaluate blood lactate, anion gap, and ionised calcium levels as poten-
tial diagnostic biomarkers in calves with atresia coli, and to identify possible predisposing
factors such as breed, gender, age, method of conception, number of lactations, and births.
The study included twenty-two calves with atresia coli and ten healthy controls, all aged
1–11 days (median, 3 days), brought to Erciyes University Veterinary Faculty from Kayseri
and nearby provinces due to non-defecation and abdominal swelling. Prominent clinical
findings among the 22 calves with atresia coli included abdominal distension in 90.9%,
anorexia in 81.8%, and depressed general posture in 86.4%. Blood gas analysis revealed
significantly elevated lactate and anion gap and decreased ionised calcium and pH in
atresia coli calves compared to controls (p < 0.05). Anion gap (>14.05 mmol/L) and ionised
calcium (<1.205 mmol/L) demonstrated high diagnostic accuracy (AUC: 0.964 and 0.872,
respectively), suggesting their potential as supportive biomarkers for early detection of
atresia coli. The study data revealed that male gender, artificial insemination, and calves
born from the third or subsequent pregnancies are statistically significant risk factors for
the development of atresia coli. Atresia coli in calves is characterized by specific clinical
signs and significant changes in blood gas parameters, such as elevated lactate and anion
gap and reduced ionised calcium and pH. Early detection using these markers can improve
diagnosis, and further studies should focus on prevention by addressing these risk factors