Influence of hydroxypropyl beta-cyclodextrin on the corneal permeation of pilocarpine


AKTAŞ Y. , Ünlü N., Orhan M., İrkeç M., Hıncal A. A.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, cilt.29, ss.223-230, 2003

  • Cilt numarası: 29 Konu: 2
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1081/ddc-120016730
  • Dergi Adı: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
  • Sayfa Sayısı: ss.223-230

Özet

The influence of hydroxypropyl beta-cyclodextrin (HPbetaCD) on the corneal permeation of pilocarpine nitrate was investigated by an in vitro permeability study using isolated rabbit cornea. Pupillary-response pattern to pilocarpine nitrate with and without HPbetaCD was examined in rabbit eye. Corneal permeation of pilocarpine nitrate was found to be four times higher after adding HPbetaCD into the formulation. The reduction of pupil diameter (miosis) by pilocarpine nitrate was significantly increased as a result of HPbetaCD addition into the simple aqueous solution of the active substance. The highest miotic response was obtained with the formulation prepared in a vehicle of Carbopol(R) 940. It is suggested that ocular bioavailability of pilocarpine nitrate could be improved by the addition of HPbetaCD.