Chloroquine Improves Adriamycin-Induced Brain Injury By Reducing Endoplasmic Reticulum Stress


Kaymak E., Akin A. T.

INSAC Natural and Health Sciences (INHS-2020), Ankara, Türkiye, 22 Mayıs - 23 Haziran 2020, ss.368

  • Basıldığı Şehir: Ankara
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayısı: ss.368

Özet




ail: tuqrul. kin@gmail. om

Abs ra t

B ckground:Adri myci (AD ) i an an hracyc ine drug use in man can er t ea ments. D sp te i s use n can er, it as lso b en sh wn to ave many s de effects. C loroqu ne CL ), is an anti-inflam atory gent se in he treatme t o many iseases s ch as ew typ coro avirus (Covi 19), m lari and rhe mat id arthrit s. The aim of his tud is o inv stiga e t e e fect of chlo oqu ne on en op asmic reticu um tress in neur toxicity c eated y A R in rats.

Metho s.Rats w re and ml divid d into 4 g oups Con rol (n = 8) CLQ (n = ) 50 m kg intr periton al y ip) as a mi i te ed da l , A R (n = 8) 2mg / kg int aper ton ally administ red ev ry 3 da s AD + CL n = ) 2mg / kg / ip AD 

+50 mg / kg ip C Q The ex eri e t la te to al o 3 d y . A the n o th e pe i en , the ats ere sacrifi ed and t e brai ti su s were em ved fro th ani als for furth r ex mina ion. istopathol gic l ch nges i brain ti sues ere eval ated and immune s ain ng was p rformed with RP78 antibody to de ermine e do lasmi reticul m str ss. Photog aph were ta en with Ol mpu BX51 micro cope nd an lyzed by he tudy group 


Results.We o served th t ADR gro p showed hi topa holog cal d teriora ion w en compare to he Contro gr up nd CL treat ent ameli ra ed this d mage ndu ed by A riamyc n.There was an incre as e in GR P 8 immü nor ea ct ivity in ADR ro up c ompa re d to t he con rol ro p. There w s a ecrea e in GRP78 immünor ac ivi y in

ADR+ Q group compared the R group 

onclusion.In ra given ADR, CLQ educes brai njury b up ssing endoplasmi etic um stress.

K words:endoplasmic reticulum stress rain driamyc n, Chl roquine

3 8 P oce din s Book ail: tuqrul. kin@gmail. om

Abs ra t

B ckground:

Adri myci (AD ) i an an hracyc ine drug use in man can er t ea ments. D sp te i s use n can er, it as lso b en sh wn to ave many s de effects. C loroqu ne CL ), is an anti-inflam atory gent se in he treatme t o many iseases s ch as ew typ coro avirus (Covi 19), m lari and rhe mat id arthrit s. The aim of his tud is o inv stiga e t e e fect of chlo oqu ne on en op asmic reticu um tress in neur toxicity c eated y A R in rats.

Metho s.

Rats w re and ml divid d into 4 g oups Con rol (n = 8) CLQ (n = ) 50 m kg intr periton al y ip) as a mi i te ed da l , A R (n = 8) 2mg / kg int aper ton ally administ red ev ry 3 da s AD + CL n = ) 2mg / kg / ip AD 

+

50 mg / kg ip C Q The ex eri e t la te to al o 3 d y . A the n o th e pe i en , the ats ere sacrifi ed and t e brai ti su s were em ved fro th ani als for furth r ex mina ion. istopathol gic l ch nges i brain ti sues ere eval ated and immune s ain ng was p rformed with RP78 antibody to de ermine e do lasmi reticul m str ss. Photog aph were ta en with Ol mpu BX51 micro cope nd an lyzed by he tudy group 

Results.

We o served th t ADR gro p showed hi topa holog cal d teriora ion w en compare to he Contro gr up nd CL treat ent ameli ra ed this d mage ndu ed by A riamyc n.

There was an incre as e in GR P 8 immü nor ea ct ivity in ADR ro up c ompa re d to t he con rol ro p. There w s a ecrea e in GRP78 immünor ac ivi y in

ADR+ Q group compared the R group 

onclusion.

In ra given ADR, CLQ educes brai njury b up ssing endoplasmi etic um stress.

K words:

endoplasmic reticulum stress rain driamyc n, Chl roquine

3 8 P oce din s Book