Akademik Veri Yönetim Sistemi
USCAP 109TH ANNUAL MEETING, California, Amerika Birleşik Devletleri, 29 Şubat - 05 Mart 2020, sa.2, ss.1
Correlation Between Fetal Autopsy and Postmortem Magnetic Resonance Imaging in Fetal Anomalies
Terminated in the Second Trimester: A Preliminary Report
Hulya Akgun1, Nahit Topaloglu2, Filiz Karaman2, Mahmut Ozgun2, Mehmet Dolanbay2, Mustafa Basbug2
1Erciyes University, Kayseri, Turkey, 2Erciyes University Medical Faculty, Kayseri, Turkey
Disclosures: Hulya Akgun: None; Nahit Topaloglu: None; Filiz Karaman: None; Mahmut Ozgun: None; Mehmet Dolanbay: None; Mustafa
Basbug: None
Background: The aim of the study was to compare the consistency of major/minor fetal anomalies detected by second trimester prenatal
ultrasound examination with the findings in fetal autopsies and postmortem magnetic resonance (PMMR) findings following the termination
of pregnancy (TOP) in the second trimester.
Design: In a 2-year long prospective study, 24 second-trimester TOP was performed due to fetal malformation diagnosed by second
trimester-ultrasound examination at a tertiary referral center. All women accepted a postmortem MRI and an autopsy of the fetus. Prenatal
ultrasound findings were compared with fetal autopsy and PMMR findings.
Results: We performed autopsy and postmortem magnetic resonance imaging in 24 fetuses. All fetuses had a postmortem whole body
magnetic resonance completed before autopsy. There were central nervous system (CNS) anomalies (n=12), gastrointestinal tract
anomalies (n=4) (including diaphragmatic hernia (n=2) Figure1-2), urinary tract malformations (n=3), musculoskeletal anomalies (n=2),
cardiovascular anomalies (n=1), ascites (n=2). PMMR confirmed all CNS anomalies and major anomalies. Four extremity anomalies
including polydactyl, (n=2), syndactyly (n=1), absence of foot (n=1), ventricular septal defect (n=1) and cleft lip and palate (n=1) were
detected during autopsy but were not confirmed during the PMMR. Autopsy was not detected cerebellar hypoplasia (n=2), corpus callosum
agenesis (n=2), chiari type 2 malformations (n=2), all were confirmed by PMMR. Among them, two CNS malformations were not detected
by autopsy due to autolysis. When comparing the prenatal ultrasound, postmortem autopsy and PMMR, there were complete agreement in
14 cases (58%) and major agreement with additional findings in 10 cases (42%). There were no cases in total disagreement.