This case report aims to evaluate the effect of ivermectin in the treatment of a horse with papillomatosis. The horse was a 14-month-old mare, with cutaneous papillomatosis diagnosed by clinical and histopahological examinations. The history revealed that papillomas had developed and progressed in the last 2 months. A single shot of ivermectin (Eqvalan paste(R), Topkim. Turkey) at a dose of 200 mcg/kg was orally administered to the horse. The horse was observed at 7(th), 15(th) and 30(th) days and no other treatment during the recovery period. Papillomas regressed clearly on the 7(th) day after the administration of ivermectin treatment and regressed nearly 90% on the 15(th) day and, showed complete remission on the 30(th) day. The results obtained in this case indicated that ivermectin might be effect in the treatment of equine papillomatosis.