Comparison of the Effects of Autologous Cytokine-Rich Serum (ACRS) and Platelet-Rich Plasma (PRP) on Skin Wound Healing

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Erol H., Karakas E., Ermis M., Akcakavak G., Aslan N. E., Karatas O.

ACTA VETERINARIA, cilt.75, sa.2, ss.151-165, 2025 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 75 Sayı: 2
  • Basım Tarihi: 2025
  • Doi Numarası: 10.2478/acve-2025-0013
  • Dergi Adı: ACTA VETERINARIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Central & Eastern European Academic Source (CEEAS), EMBASE, Food Science & Technology Abstracts, Veterinary Science Database, Directory of Open Access Journals
  • Sayfa Sayıları: ss.151-165
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Erciyes Üniversitesi Adresli: Evet

Özet

Wound healing is one of the most complex biological events, involving physiological

processes such as tissue restoration and intricate cellular and molecular activities. The

aim of this study was to investigate the effects of Autologous Cytokine Rich Serum

(ACRS) and Platelet-rich plasma (PRP) on wound healing and to compare their impact

on tissue repair using histopathological and immunohistochemical methods. A total

of 42 healthy Wistar-Albino rats were used as material. The histopathological and

immunohistochemical evaluations showed that ACRS is more effective than PRP

on wound healing. The superior efficacy of ACRS is attributed to its stimulation of

anti-inflammatory cytokines and provision of essential nutrients such as amino acids,

vitamins, and lipids. Further detailed studies are recommended to explore these findings.