Synthesis and antimicrobial activities of novel bisacridine-1,8-dione derivatives

Kaya M., Yildirir Y., Celik G. Y.

MEDICINAL CHEMISTRY RESEARCH, vol.20, no.3, pp.293-299, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 3
  • Publication Date: 2011
  • Doi Number: 10.1007/s00044-010-9321-6
  • Journal Name: MEDICINAL CHEMISTRY RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.293-299
  • Keywords: Bisacridine-1,8-diones, Antimicrobial activity, Antibiotics, SODIUM-HYDROGEN SULFATE, BIOLOGICAL-ACTIVITY, ACRIDINE, DEPROTECTION, EFFICIENT, MONO
  • Erciyes University Affiliated: Yes

Abstract

A series of bisacridine-1,8-dione derivatives were synthesized by one-pot reaction of aromatic dialdehydes, dimedone or cyclohexane-1,3-dione and primer aromatic amines in acetonitrile to utilizing Amberlyst-15 as a heterogeneous catalyst. The structures of compounds were characterized by FT-IR, NMR, and elemental analysis. Antimicrobial activities of these compounds were determined by using the disc diffusion method against to these gram-positive and gram-negative bacteria and yeast. The results were compared with reference discs.