Pain Management Nursing, 2026 (SCI-Expanded, SSCI, Scopus)
Background Pain during arteriovenous fistula (AVF) catheterization is a common discomfort faced by hemodialysis patients and can negatively affect treatment adherence, satisfaction, and overall quality of life. Effective pain management strategies are crucial to improving patient comfort during vascular access procedures. Aim This study aimed to evaluate the effectiveness of topical lidocaine and benzocaine in reducing pain and enhancing injection satisfaction during AVF catheterization among hemodialysis patients. Design A randomized controlled trial was conducted with 60 hemodialysis patients who met the inclusion criteria. Methods Participants were randomly assigned to three groups: Lidocaine spray (n = 20), benzocaine spray (n = 20), and Placebo (n = 20). Pain intensity and injection satisfaction were measured immediately after catheterization using the visual analogue scale and the Injection Satisfaction Scale. Hemodynamic parameters were recorded pre- and postprocedure. Data were analyzed using ANOVA, paired t -test, Kruskal–Wallis test, Dunn’s test, and Pearson’s correlation analysis, with a significance level of p < .05. Results Pain scores were significantly lower in the lidocaine and benzocaine groups compared to the placebo group (p = .002). Injection satisfaction scores were significantly higher in both intervention groups compared to the placebo group (p < .001). No significant difference was observed between the lidocaine and benzocaine groups regarding pain and injection satisfaction scores (p > .05). A moderate negative correlation was found between pain intensity and injection satisfaction. Conclusions Both lidocaine and benzocaine were found to be effective in reducing pain and enhancing injection satisfaction during AVF catheterization. Further multicenter trials with larger sample sizes are recommended to support the generalizability of these findings in clinical settings.