Eco-Friendly Synthesis of Copper Nanoflowers Using Rheum Cordatum Losinsk Leaf Extracts for Photocatalytic Dye Degradation and Biomedical Applications

Yıldırım M., Yilmaz B. S., Çimentepe M., Necip A., Asfoor A., Hord B.

Cell Biochemistry and Biophysics, 2026 (SCI-Expanded, Scopus) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1007/s12013-026-02002-6
  • Dergi Adı: Cell Biochemistry and Biophysics
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, MEDLINE
  • Anahtar Kelimeler: Rheum Cordatum losinsk, Nanoflower, Antioxidant, Antimicrobial, Dye degradation
  • Erciyes Üniversitesi Adresli: Evet

Özet

In this study, copper nanoflowers were synthesized using Rheum cordatum Losinsk leaf extracts. The synthesized hybrid nanoflowers were systematically evaluated for their antibacterial, antibiofilm, antioxidant, and acetylcholinesterase (AChE) inhibitory properties, as well as their potential in methylene blue (MB) dye removal. According to the obtained results, the nanoflowers demonstrated a 70% removal efficiency for MB dye and exhibited an IC₅₀ value of 55 µg/mL for AChE inhibition, 561 µg/mL for DPPH, and 411 µg/mL for ABTS radical scavenging assays. Compared with the plant extracts, the synthesized nanoflowers showed significantly enhanced antibacterial performance, with a minimum inhibitory concentration (MIC) of 32 µg/mL against Staphylococcus aureus and the highest activity against methicillin-resistant S. aureus (MRSA) with an MIC of 256 µg/mL. At a concentration of 1024 µg/mL, RCL@Cu-hNFs reduced biofilm formation by 70.2% in MRSA and 66.7% in multidrug-resistant Escherichia coli.