Investigation of antiulcer activities of imidazo[1,2-alpha]pyridinyl-2-alkylaminobenzoxazoles and 5,6,7,8-tetahydroimidazo[1,2-alpha]pyridinylbenzoxazoles with electron-topological (ET) method

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Guzel Y., Kopar A.

ARCHIV DER PHARMAZIE, vol.335, pp.27-32, 2002 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 335
• Publication Date: 2002
• Doi Number: 10.1002/1521-4184(200201)335:1<27::aid-ardp27>3.0.co;2-v
• Journal Name: ARCHIV DER PHARMAZIE
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.27-32
• Keywords: antiulcer activity, structure-activity relationship, electronic structure, SCH-28080
• Erciyes University Affiliated: Yes

Abstract

The study presents structure-activity considerations of a series of imidazo[1,2-alpha]pyridiny-2-alkylaminobenzoxazoles(l) and 5,6,7,8-tetahydroimidazo[1,2-alpha]pyridinylbenzoxazoles (II) investigated for anti-stress ulcer activity with the electron-topological method. A series of 39 compounds including 24 active and 15 weakly active was studied. It is shown that the fragment determined by the electron-topological method in an active molecule is responsible for anti-stress ulcer activity. Quantitative structure-activity relationships with electron topological approach of these compounds are discussed in terms of the statistical program STATGRAF-7.0.