Investigation of antiulcer activities of imidazo[1,2-alpha]pyridinyl-2-alkylaminobenzoxazoles and 5,6,7,8-tetahydroimidazo[1,2-alpha]pyridinylbenzoxazoles with electron-topological (ET) method


Guzel Y. , Kopar A.

ARCHIV DER PHARMAZIE, vol.335, pp.27-32, 2002 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 335
  • Publication Date: 2002
  • Doi Number: 10.1002/1521-4184(200201)335:1<27::aid-ardp27>3.0.co;2-v
  • Title of Journal : ARCHIV DER PHARMAZIE
  • Page Numbers: pp.27-32
  • Keywords: antiulcer activity, structure-activity relationship, electronic structure, SCH-28080

Abstract

The study presents structure-activity considerations of a series of imidazo[1,2-alpha]pyridiny-2-alkylaminobenzoxazoles(l) and 5,6,7,8-tetahydroimidazo[1,2-alpha]pyridinylbenzoxazoles (II) investigated for anti-stress ulcer activity with the electron-topological method. A series of 39 compounds including 24 active and 15 weakly active was studied. It is shown that the fragment determined by the electron-topological method in an active molecule is responsible for anti-stress ulcer activity. Quantitative structure-activity relationships with electron topological approach of these compounds are discussed in terms of the statistical program STATGRAF-7.0.