Investigation of antiulcer activities of imidazo[1,2-alpha]pyridinyl-2-alkylaminobenzoxazoles and 5,6,7,8-tetahydroimidazo[1,2-alpha]pyridinylbenzoxazoles with electron-topological (ET) method

Guzel Y., Kopar A.

ARCHIV DER PHARMAZIE, cilt.335, ss.27-32, 2002 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 335
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1002/1521-4184(200201)335:1<27::aid-ardp27>3.0.co;2-v
  • Dergi Adı: ARCHIV DER PHARMAZIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.27-32
  • Anahtar Kelimeler: antiulcer activity, structure-activity relationship, electronic structure, SCH-28080
  • Erciyes Üniversitesi Adresli: Evet

Özet

The study presents structure-activity considerations of a series of imidazo[1,2-alpha]pyridiny-2-alkylaminobenzoxazoles(l) and 5,6,7,8-tetahydroimidazo[1,2-alpha]pyridinylbenzoxazoles (II) investigated for anti-stress ulcer activity with the electron-topological method. A series of 39 compounds including 24 active and 15 weakly active was studied. It is shown that the fragment determined by the electron-topological method in an active molecule is responsible for anti-stress ulcer activity. Quantitative structure-activity relationships with electron topological approach of these compounds are discussed in terms of the statistical program STATGRAF-7.0.