In this study, dynamically loaded sandwich panels with two different core materials and face sheets made of aluminum alloys (6061-T6) were investigated experimentally and numerically under low-velocity impact. Polypropylene, PP (C3H6)(n) honeycomb and extruded polystyrene foam, XPS (C8H8)(n) were preferred as core material. By using the contact force and kinetic energy changes, which were the impact test results of the sandwich panels, the contact and impact resistance was examined. As a result of the tests, damaged regions and permanent central displacement were determined and energy absorption capabilities were demonstrated for two different structures. The results obtained were compared with the results obtained by the open finite element method. In this study, it was shown that the face-sheet thickness of sandwich panels was an important parameter affecting the impact behavior. The behavior of the core material when the face-sheet loses its rigidity was investigated and it was found that polystyrene foam was more effective in preventing impact damage. However, it was found that using the PP honeycomb or XPS was affected the impact behavior in different points.