A biochemical and immunohistochemical study of the protective effects of carnosine for carbon tetrachloride induced liver injury in rats

KULOGLU N., Sonmez M. F.

BIOTECHNIC & HISTOCHEMISTRY, vol.90, no.8, pp.608-614, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 90 Issue: 8
  • Publication Date: 2015
  • Doi Number: 10.3109/10520295.2015.1044565
  • Page Numbers: pp.608-614


We investigated the protective effect of carnosine on carbon tetrachloride-induced liver tissue damage. Thirty-two adult male rats were divided into four equal groups. Group 1 was the untreated control, group 2 was injected with 0.2 ml/kg/day carbon tetrachloride, group 3 was injected with with 0.2 ml/kg/day carbon tetrachloride plus 200 mg/kg/day carnosine, and group 4 was injected with 200 mg/kg/day carnosine. Increased serum alanine amino transferase and aspartate amino transferase levels, liver malondialdehyde levels, HSP-70 expression and steatosis were observed following treatment with carbon tetrachloride. Carbon tetrachloride caused severe biochemical and histopathological changes in liver tissue and treatment with carnosine partially prevented the damage. HSP-70 may help control liver damage.