Reduction of the argyrophilic nucleolar organizing region associated protein synthesis with age in buccal epithelial cells of healthy individuals

SELVI B., Demirtas H., Eroz R., Imamoglu N. N.

AGING CLINICAL AND EXPERIMENTAL RESEARCH, vol.27, no.2, pp.201-208, 2015 (SCI-Expanded) identifier identifier identifier


Background Nucleolus organizer regions (NORs) consist of the rRNA coding gene family (rDNA) in the cell nucleus. The argyrophilic proteins are selectively stained with silver nitrate and bind these regions. It was reported that NOR (rDNA) activity decreases in human lymphocytes, fibroblasts and bone marrow with age. However, to our knowledge there have not been any studies related to the NORs in oral epithelial cells of healthy individuals.