Reduction of the argyrophilic nucleolar organizing region associated protein synthesis with age in buccal epithelial cells of healthy individuals

SELVI, Burak; Demirtas, Halil; Eroz, Recep; Imamoglu, NEFİSE

doi:10.1007/s40520-014-0263-6

Reduction of the argyrophilic nucleolar organizing region associated protein synthesis with age in buccal epithelial cells of healthy individuals

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SELVI B., Demirtas H., Eroz R., Imamoglu N. N.

AGING CLINICAL AND EXPERIMENTAL RESEARCH, vol.27, no.2, pp.201-208, 2015 (SCI-Expanded)

Publication Type: Article / Article
Volume: 27 Issue: 2
Publication Date: 2015
Doi Number: 10.1007/s40520-014-0263-6
Journal Name: AGING CLINICAL AND EXPERIMENTAL RESEARCH
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.201-208
Erciyes University Affiliated: Yes

Abstract

Background Nucleolus organizer regions (NORs) consist of the rRNA coding gene family (rDNA) in the cell nucleus. The argyrophilic proteins are selectively stained with silver nitrate and bind these regions. It was reported that NOR (rDNA) activity decreases in human lymphocytes, fibroblasts and bone marrow with age. However, to our knowledge there have not been any studies related to the NORs in oral epithelial cells of healthy individuals.