Electrospinning of ampicillin trihydrate loaded electrospun PLA nanofibers I: effect of polymer concentration and PCL addition on its morphology, drug delivery and mechanical properties


EREN BÖNCÜ T. , Ozdemir N.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, 2021 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume:
  • Publication Date: 2021
  • Doi Number: 10.1080/00914037.2021.1876057
  • Title of Journal : INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS

Abstract

It was aimed to produce ampicillin trihydrate loaded electrospun PLA and PLA/PCL nanofibers using HFIP as solvent. The effect of PLA concentration (7.5-12.5%), PCL addition and added PCL amount (20-80%) on the nanofibers properties were investigated. The increase in PLA concentration caused an increase in nanofiber diameter and a decrease in mechanical properties. PLA nanofibers have shown biphasic controlled drug release up to 10 days, while PCL nanofiber caused only a rapid burst effect. As a result, PLA concentration and the amount of added PCL affected the average nanofiber diameter, in vitro drug release and mechanical properties of the obtained electrospun nanofibers.