Electrospinning of ampicillin trihydrate loaded electrospun PLA nanofibers I: effect of polymer concentration and PCL addition on its morphology, drug delivery and mechanical properties
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, vol.71, no.9, pp.669-676, 2022 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 71 Issue: 9
- Publication Date: 2022
- Doi Number: 10.1080/00914037.2021.1876057
- Journal Name: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chimica, Compendex, INSPEC
- Page Numbers: pp.669-676
- Keywords: Ampicillin trihydrate, electrospinning, HFIP (1, 1, 1, 3, 3, 3-Hexafluoro-2-propanol), nanofiber, PCL (polycaprolactone), PLA (polylactic acid), PLA, PCL nanofiber
- Erciyes University Affiliated: Yes
Abstract
It was aimed to produce ampicillin trihydrate loaded electrospun PLA and PLA/PCL nanofibers using HFIP as solvent. The effect of PLA concentration (7.5-12.5%), PCL addition and added PCL amount (20-80%) on the nanofibers properties were investigated. The increase in PLA concentration caused an increase in nanofiber diameter and a decrease in mechanical properties. PLA nanofibers have shown biphasic controlled drug release up to 10 days, while PCL nanofiber caused only a rapid burst effect. As a result, PLA concentration and the amount of added PCL affected the average nanofiber diameter, in vitro drug release and mechanical properties of the obtained electrospun nanofibers.