Glycoxidative and nitrosative stress in kidney of experimental diabetic rats: Effects of the prydoindole antioxidant stobadine


Cumaoglu A. , Stefek M., Bauer V., Ari N., Aricioglu A., KARASU Ç.

NEUROENDOCRINOLOGY LETTERS, vol.31, no.3, pp.313-318, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 3
  • Publication Date: 2010
  • Title of Journal : NEUROENDOCRINOLOGY LETTERS
  • Page Numbers: pp.313-318

Abstract

OBJECTIVES: Recent basic research and clinical data have provided new insights into the role of glycoxidative and nitrosative stresses (both oxidative stress) in diabetic complications, such as diabetic nephropathy, suggesting a different and innovative approach to antioxidant therapy. In streptozotocin-induced diabetic rat kidney, the present study investigated the effects of the sythetic pyridoindole antioxidant stobadine (STB) on renal total antioxidant potential (AOP) and protein oxidation parameters such as protein carbonyl content (PCC), advanced oxidation protein products (AOPPs) and nitrotyrosine (NT), a marker specific for protein modification by peroxynitrite.