The effects of dexmedetomidine on mesenteric arterial occlusion-associated gut ischemia and reperfusion-induced gut and kidney injury in rabbits

Kilic, Kemal; Hanci, Volkan; Selek, Sahbettin; Sozmen, Mahmut; Kilic, Nergiz; Citil, MEHMET; YURTLU, Derya; Yurtlu, B.

doi:10.1016/j.jss.2012.03.073

The effects of dexmedetomidine on mesenteric arterial occlusion-associated gut ischemia and reperfusion-induced gut and kidney injury in rabbits

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Kilic K., Hanci V., Selek S., Sozmen M., Kilic N., Citil M., ...More

JOURNAL OF SURGICAL RESEARCH, vol.178, no.1, pp.223-232, 2012 (SCI-Expanded)

Publication Type: Article / Article
Volume: 178 Issue: 1
Publication Date: 2012
Doi Number: 10.1016/j.jss.2012.03.073
Journal Name: JOURNAL OF SURGICAL RESEARCH
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.223-232
Keywords: Experimental mesenteric ischemia, Dexmedetomidine, Renal, Intestinal, Rabbit, Mesenteric artery occlusion, INTESTINAL ISCHEMIA/REPERFUSION INJURY, CRITICALLY-ILL PATIENTS, INFLAMMATORY RESPONSES, CEREBRAL-ISCHEMIA, GLOBAL-ISCHEMIA, NITRIC-OXIDE, ALPHA-2-ADRENOCEPTOR AGONIST, SUPEROXIDE-DISMUTASE, RAT-KIDNEY, MODEL
Erciyes University Affiliated: No

Abstract

Objective: We assessed the antioxidant activity of dexmedetomidine (Dex) administered during the ischemic period in a rabbit model of mesenteric ischemia/reperfusion (I/R) injury using biochemical and histopathological methods.