The efficacy of nebulized salbutamol, magnesium sulfate, and salbutamol/magnesium sulfate combination in moderate bronchiolitis


KÖSE M. , ÖZTÜRK M. A. , Poyrazoglu H., Elmas T. , Ekinci D. , Tubas F. , ...More

EUROPEAN JOURNAL OF PEDIATRICS, vol.173, no.9, pp.1157-1160, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 173 Issue: 9
  • Publication Date: 2014
  • Doi Number: 10.1007/s00431-014-2309-3
  • Title of Journal : EUROPEAN JOURNAL OF PEDIATRICS
  • Page Numbers: pp.1157-1160
  • Keywords: Magnesium sulfate, Salbutamol, Bronchiolitis, LUNG INJURY, HISTAMINE, ASTHMA

Abstract

The aim of this paper is to compare the effect of nebulized magnesium sulfate to nebulized salbutamol and salbutamol/magnesium sulfate on successful discharge from the emergency department. A total of 56 infants were included in this double-blinded, prospective study. Infants were grouped according to the nebulized treatment they received: group 1-salbutamol/normal saline, group 2-magnesium sulfate and normal saline, and group 3-salbutamol plus magnesium sulfate. Heart beat, bronchiolitis, clinical severity scores (CSS), and oxygen saturation of the patients were determined before and after nebulization (0, 1, 4 h). The patients were monitored for adverse reactions. Post-treatment mean CSS results were significantly lower than pre-treatment scores in all groups at 4 h with no significant difference within groups. CSS scores were lower in the salbutamol/magnesium sulfate group when compared with the magnesium sulfate and salbutamol groups (3.4 (2.4-4.3), 4.7 (3.8-5.7), 4.0 (3.2-4.3)). CSS were significantly lower than those from the magnesium sulfate group. Conclusion: Nebulized magnesium sulfate plus salbutamol may have additive effects for improving the short-term CSS.