In the present study, 40 male Wistar albino rats were used and divided into 4 groups The first group served as the control group, the second group was administered Saw palmetto extract at the dose of 20 mg/kg/bw, the third group was administered flumethrin at the close of 15 mg/kg/bw, and the fourth group was administered a combination of 20 mg/kg/bw Saw palmetto extract and 15 mg/kg/bw flumethrin, for 21 days, orally. After the trial period, blood and tissue (liver, kidney and brain) samples were taken nom the rats. Saw palmetto extract did not cause significant alterations in plasma and tissue malondialdehyde (MDA) levels, serum and tissue nitric oxide (NO) levels, erythrocyte and tissue superoxide dismutase (SOD). catalase (CAT) and glutathione peroxidase (GSH-Px) activities when compared to the controls (p > 005). Flumethrin led to increased plasma and tissue MDA levels, serum and tissue NO levels, tissue GSH-Px activities and decreased erythrocyte and tissue SOD and CAT activities, and erythrocyte GSH-Px activity, compared to the controls (p < 0 05) The flumethrin and Saw palmetto extract combination increased erythrocyte SOD activity and decreased brain GSH-Px activity as compared to flumethrin (p < 0 05) In conclusion, it was determined that Saw palmetto extract did not cause any negative effect on the prooxidant-antioxidant balance. While flumethrin stimulated lipid peroxidation, Saw palmetto extract at the dose of 20 mg/kg/bw did not exhibit enough antioxidant effect in rats (C) 2010 Elsevier Inc All rights reserved.