Collet-Sicard syndrome is characterized by the unilateral paralysis of cranial nerves IX-XII. The most common cause is an extradural tumor in the posterior fossa. This syndrome may occasionally occur because of distant metastases. Collet-Sicard syndrome which results from metastatic prostate carcinoma is very rare. A review of the English literature showed that this is the second report of metastatic prostate carcinoma with Collet-Sicard syndrome and dysfunctions of cranial nerves VII and VIII. On the other hand, this is the first report of a patient with prostate carcinoma who initially presented with Collet-Sicard syndrome and showed dysfunctions of cranial nerves VII and VIII.