Biomimetic cell membrane-coated poly(lactic-co-glycolic acid) nanoparticles for biomedical applications

Jan N., Madni A., Khan S., Shah H., Akram F., Khan A., ...Daha Fazla

BIOENGINEERING & TRANSLATIONAL MEDICINE, cilt.8, sa.2, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 8 Sayı: 2
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1002/btm2.10441
  • Dergi Adı: BIOENGINEERING & TRANSLATIONAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: biodegradable, biomimetic, cell-membrane, drug delivery, PLGA, targeted delivery
  • Erciyes Üniversitesi Adresli: Evet

Özet

Poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) are commonly used for drug delivery because of their favored biocompatibility and suitability for sustained and controlled drug release. To prolong NP circulation time, enable target-specific drug delivery and overcome physiological barriers, NPs camouflaged in cell membranes have been developed and evaluated to improve drug delivery. Here, we discuss recent advances in cell membrane-coated PLGA NPs, their preparation methods, and their application to cancer therapy, management of inflammation, treatment of cardiovascular disease and control of infection. We address the current challenges and highlight future research directions needed for effective use of cell membrane-camouflaged NPs.