Role of vascular calcification inhibitors in preventing vascular dysfunction and mortality in hemodialysis patients

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Gungor O., KOÇYİĞİT I., YILMAZ M. I., Sezer S.

SEMINARS IN DIALYSIS, cilt.31, sa.1, ss.72-81, 2018 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 31 Sayı: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1111/sdi.12616
  • Dergi Adı: SEMINARS IN DIALYSIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.72-81
  • Erciyes Üniversitesi Adresli: Evet

Özet

Cardiovascular events make up the primary cause of death in hemodialysis patients, and the risk for cardiovascular mortality is significantly increased by vascular calcification, a condition observed frequently in this patient population. The mechanisms underlying the pathogenesis of vascular calcification are complex, and many factors facilitate or hinder the development of calcification. In this review, we first summarize the main factors contributing to the pathogenesis of vascular calcification in patients with end-stage renal disease. We then explore the role of calcification inhibitors in the calcification process, as well as their effect on vascular dysfunction and mortality in hemodialysis patients.