Intracranial hemorrhages and late hemorrhagic disease associated cholestatic liver disease

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PER H., ARSLAN D., GÜMÜŞ H., COŞKUN A., KUMANDAŞ S.

NEUROLOGICAL SCIENCES, cilt.34, sa.1, ss.51-56, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1007/s10072-012-0965-5
  • Dergi Adı: NEUROLOGICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.51-56
  • Anahtar Kelimeler: Intracranial bleeding, Late hemorrhagic disease, Liver disease, VITAMIN-K-DEFICIENCY, BLEEDING VKDB, PROPHYLAXIS, PHYLLOQUINONE, NEWBORN, INFANTS
  • Erciyes Üniversitesi Adresli: Evet

Özet

Deficiency of vitamin K predisposes to early, classic or late hemorrhagic disease of the newborn (HDN); of which late HDN may be associated with serious and life-threatening intracranial hemorrhage. Late HDN is characterized intracranial bleeding in infants aged 1 week to 6 months due to severe vitamin K deficiency. Late HDN is still an important cause of mortality and morbidity in developing countries where vitamin K prophylaxis is not routinely practiced. Children with cholestatic liver disease are at risk for developing secondary vitamin K deficiency because of fat malabsorbtion and inadequate dietary intake. In this study, we described 11 infants with cholestatic liver disease with different etiologies exhibiting intracranial hemorrhage (ICH). Six patients underwent surgical evacuation of ICH, following the administration of vitamin K and/or fresh frozen plasma. The possibility of cholestatic liver disease should be considered in the treatment of ICH due to vitamin K deficiency.