IL-15 negatively regulates curdlan-induced IL-23 production by human monocyte-derived dendritic cells and subsequent Th17 response

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EKEN A., Okus F. Z., Erdem S., Azizoglu Z. B., Haliloglu Y., Bicer A., ...More

NORTHERN CLINICS OF ISTANBUL, vol.6, no.4, pp.379-387, 2019 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 4
  • Publication Date: 2019
  • Doi Number: 10.14744/nci.2019.38802
  • Journal Name: NORTHERN CLINICS OF ISTANBUL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.379-387
  • Keywords: Dendritic cell, IL-15, Th17, IL-23, DIFFERENTIATION, INTERLEUKIN-15, CYTOKINE, INNATE, EXPRESSION, COLITIS, PROTEIN, CLONING, STAT5, CHAIN
  • Erciyes University Affiliated: Yes

Abstract

OBJECTIVE: In this study, we aimed to assess the effects of long- and short-term IL-15 cytokine exposure of human monocyte-derived curdlan-matured dendritic cells (DCs) on the production of Th17 cell-polarizing cytokine IL-23 and subsequent Th17 cell activation.