IL-15 negatively regulates curdlan-induced IL-23 production by human monocyte-derived dendritic cells and subsequent Th17 response

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EKEN A., Okus F. Z., Erdem S., Azizoglu Z. B., Haliloglu Y., Bicer A., ...Daha Fazla

NORTHERN CLINICS OF ISTANBUL, cilt.6, sa.4, ss.379-387, 2019 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 6 Sayı: 4
  • Basım Tarihi: 2019
  • Doi Numarası: 10.14744/nci.2019.38802
  • Dergi Adı: NORTHERN CLINICS OF ISTANBUL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.379-387
  • Anahtar Kelimeler: Dendritic cell, IL-15, Th17, IL-23, DIFFERENTIATION, INTERLEUKIN-15, CYTOKINE, INNATE, EXPRESSION, COLITIS, PROTEIN, CLONING, STAT5, CHAIN
  • Erciyes Üniversitesi Adresli: Evet

Özet

OBJECTIVE: In this study, we aimed to assess the effects of long- and short-term IL-15 cytokine exposure of human monocyte-derived curdlan-matured dendritic cells (DCs) on the production of Th17 cell-polarizing cytokine IL-23 and subsequent Th17 cell activation.