Role of kallistatin in pediatric patients with pulmonary arterial hypertension

Pamukcu O., Ay D., ÜZÜM K., Barlakketi D., KÖSE M., BAYKAN A., ...More

TURKISH JOURNAL OF PEDIATRICS, vol.62, no.3, pp.405-410, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 62 Issue: 3
  • Publication Date: 2020
  • Doi Number: 10.24953/turkjped.2020.03.007
  • Journal Name: TURKISH JOURNAL OF PEDIATRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.405-410
  • Erciyes University Affiliated: Yes

Abstract

Background and objectives. Kallistatin, a serine proteinase inhibitor, exerts its effect by vascular repair, angiogenesis inhibition, strong vasodilation, inhibition of vascular endothelial growth factor (VEGF), anti-inflammation, and anti-apoptosis. We hypothesized as to whether it has a protective role in pulmonary arterial hypertension (PAH).