Role of kallistatin in pediatric patients with pulmonary arterial hypertension

Pamukcu O., Ay D., ÜZÜM K., Barlakketi D., KÖSE M., BAYKAN A., ...Daha Fazla

TURKISH JOURNAL OF PEDIATRICS, cilt.62, sa.3, ss.405-410, 2020 (SCI-Expanded, Scopus, TRDizin) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 62 Sayı: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.24953/turkjped.2020.03.007
  • Dergi Adı: TURKISH JOURNAL OF PEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.405-410
  • Anahtar Kelimeler: kallistatin, pulmonary hypertension, TNF alpha, IL-10
  • Erciyes Üniversitesi Adresli: Evet

Özet

Background and objectives. Kallistatin, a serine proteinase inhibitor, exerts its effect by vascular repair, angiogenesis inhibition, strong vasodilation, inhibition of vascular endothelial growth factor (VEGF), anti-inflammation, and anti-apoptosis. We hypothesized as to whether it has a protective role in pulmonary arterial hypertension (PAH).