Intensive care is a form of multidisciplinary care and treatment given to patients who have an acute life-threatening disease or who are expected to develop such disease. Talking with patients and interacting with intubated patients in the ICU can have a positive effect. It is stated that the patients who are described as unconscious do not hear what is going on around them and are not aware of it. However, families say that their patients react to them. In this study, unlike the literature studies, EEG and GSR signals were obtained from unconscious patients hospitalized in the ICU. It is aimed to examine the effects of family members and nurses such as physical touch and speech to the patient by analyzing the physiological signals of the patient using signal processing methods. Statistical analysis was performed as a result of feature extraction from EEG and GSR signals. As a result, it was observed that the patient's physiological signals changed when interacted with family members and nurse.