Efficacy of Hair Mesotherapy With Biomimetic Peptides and Micronutrients in Patients With Androgenetic Alopecia: A Retrospective Observational Study
Journal of Cosmetic Dermatology, cilt.25, sa.6, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 25 Sayı: 6
- Basım Tarihi: 2026
- Doi Numarası: 10.1111/jocd.70993
- Dergi Adı: Journal of Cosmetic Dermatology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest)
- Anahtar Kelimeler: androgenetic alopecia, biomimetic peptides, hair loss, mesotherapy, micronutrients
- Erciyes Üniversitesi Adresli: Evet
Özet
Background: Hair mesotherapy is increasingly used in the management of androgenetic alopecia (AGA), yet standardized treatment protocols and controlled clinical data are limited. Aims: This study aimed to evaluate the efficacy and safety of a mesotherapy formulation containing biomimetic peptides, vitamins, and micronutrients in patients with AGA. Patients/Methods: We conducted a retrospective observational study including 50 patients clinically diagnosed with AGA. Mesotherapy was administered using a mesogun for eight sessions over 3 months. Each session involved 3 mL of mesotherapy solution containing biomimetic peptides, vitamins, and micronutrients. Clinical, trichoscopic, and Trichoscan assessments were performed before treatment and 4 weeks after the final session. Results: Post-treatment, significant improvements were observed in trichoscopic parameters, including reduced hair diameter variability (p < 0.01), decreased empty follicles (p = 0.012), and increased upright vellus hairs (p < 0.01). Trichoscan analysis demonstrated significant increases in total hair count, hair density, average hair thickness, terminal hair density, and terminal hair ratio (all p < 0.001). Treatment was well-tolerated, with only mild, transient pain reported. Conclusions: Hair mesotherapy with biomimetic peptides and micronutrients appears to be a promising and well-tolerated therapeutic option for AGA. Larger prospective controlled trials are needed to validate these findings.