Akademik Veri Yönetim Sistemi
Analytical Letters, 2026 (SCI-Expanded, Scopus)
The development of cost-effective and sensitive electrochemical platforms for therapeutic drug monitoring remains a significant challenge, particularly for antipsychotic agents such as risperidone (Risp). In this work, a zirconium-based metal–organic framework (UiO-66) was employed as a high-surface-area electrocatalytic interface on a screen-printed carbon electrode (SPCE) to construct an adsorption-assisted electrochemical sensing platform for Risp detection. The porous architecture of UiO-66(Zr) provides a higher accumulation of Risp molecules by means of surface interactions, resulting in enhanced electron transfer kinetics and higher oxidation signals. Electrochemical studies showed that oxidation of Risp is promoted by an adsorption-controlled proton-coupled electron transfer. Differential pulse voltammetry under the optimized conditions showed a broad linear response range (0.5–120 µM) and a very good linearity (R2 = 0.9993). The electrode was modified to be highly selective to structurally related compounds and common biological interferents. The applicability of the sensor was investigated in synthetic urine, saliva and tap water with satisfactory recoveries (96.3-101.8%) and good precision. The synergistic effect of the UiO-66(Zr) porous architecture and the preconcentration of the analyte at the electrode surface explain the improvement in the sensing performance. The results of this study show that electrochemical platforms based on MOFs are simple, low-cost, and efficient tools for point-of-care monitoring and pharmaceutical analysis applications.