Akademik Veri Yönetim Sistemi
FRONTIERS IN BIOSCIENCE-LANDMARK, cilt.28, sa.12, ss.353-0, 2023 (SCI-Expanded)
Background: The current research centers on exploring the antioxidant, antimicrobial, and antidiabetic features of Schinus molle L. grown in Turkey. Methods: Quantitative analysis of chlorogenic acid, caffeic acid, and hyperoside levels in leaf, ripe fruit, and raw fruit extracts was conducted using High-Performance Liquid Chromatography (HPLC) in a 70% methanol-water mixture. Among the extracts, the methanol extract from ripe fruits displayed the highest chlorogenic acid concentration, measuring at 2.040% +/- 0.172% standard deviation (SD). Moreover, analysis of their total phenolic and flavonoid contents was carried out. Antioxidant power was assessed through different chemical assays, together with their antimicrobial and anti-diabetic properties. Results: The results of DPPH (2,2-Diphenyl-1-picrylhydrazyl), ABTS (2,2 '-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), and reducing power assays showed that leaf and ripe fruit alcoholic extract exhibited peak performance. While the MIC ( minimum inhibitory concentration) values of the extracts were determined to have moderate bactericidal effects on Staphylococcus aureus, Escherichia coli, and Candida albicans it was observed that none of the extracts displayed biofilm inhibition. The inhibition percentage of alpha-glucosidase enzyme activity for the methanol extract of raw fruits was determined to be 99.11 +/- 1.61. In diabetic beta-TC cells, glucose level was measured as 129 +/- 2.03 mg/dL, and insulin amount was measured as 37.2 +/- 0.02 mg/dL. Conclusions: The findings of our study seem to have important implications for future research, as Schinus molle L. may be a potential pharmaceutical candidate with important pharmacological activities.