Effect of kirenol on the interaction between the WNT/beta-Catenin and RUNX2/TCF/LEF1 pathways in fracture healing in vivo


KARAMAN İ., Gunay A. B. , Yerer M. B. , DEMİRPOLAT E., DOĞAN S., Yay A. H. , ...More

ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA, vol.54, no.3, pp.320-329, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 3
  • Publication Date: 2020
  • Doi Number: 10.5152/j.aott.2020.03.529
  • Journal Name: ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.320-329
  • Keywords: Herba Siegesbeckia, Kirenol, Wingless Type, beta-Catenin, rhBMP-2, OSTEOBLAST DIFFERENTIATION, SIGNALING PATHWAYS, PROLIFERATION, ACTIVATION
  • Erciyes University Affiliated: Yes

Abstract

Objective: This study aimed to determine the effects of a natural diterpenoid, kirenol, on fracture healing in vivo in an experimental rat model of femur fracture and investigate its potential mechanism of action via the Wnt/beta-catenin pathway.