Effect of kirenol on the interaction between the WNT/beta-Catenin and RUNX2/TCF/LEF1 pathways in fracture healing in vivo

KARAMAN İ., Gunay A. B., Yerer M. B., DEMİRPOLAT E., DOĞAN S., Yay A. H., ...Daha Fazla

ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA, cilt.54, sa.3, ss.320-329, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54 Sayı: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.5152/j.aott.2020.03.529
  • Dergi Adı: ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.320-329
  • Anahtar Kelimeler: Herba Siegesbeckia, Kirenol, Wingless Type, beta-Catenin, rhBMP-2, OSTEOBLAST DIFFERENTIATION, SIGNALING PATHWAYS, PROLIFERATION, ACTIVATION
  • Erciyes Üniversitesi Adresli: Evet

Özet

Objective: This study aimed to determine the effects of a natural diterpenoid, kirenol, on fracture healing in vivo in an experimental rat model of femur fracture and investigate its potential mechanism of action via the Wnt/beta-catenin pathway.