Effect of kirenol on the interaction between the WNT/beta-Catenin and RUNX2/TCF/LEF1 pathways in fracture healing in vivo


KARAMAN İ., Gunay A. B., Yerer M. B., DEMİRPOLAT E., DOĞAN S., Yay A. H., ...More

ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA, vol.54, no.3, pp.320-329, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 3
  • Publication Date: 2020
  • Doi Number: 10.5152/j.aott.2020.03.529
  • Journal Name: ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.320-329
  • Keywords: Herba Siegesbeckia, Kirenol, Wingless Type, beta-Catenin, rhBMP-2, OSTEOBLAST DIFFERENTIATION, SIGNALING PATHWAYS, PROLIFERATION, ACTIVATION
  • Erciyes University Affiliated: Yes

Abstract

Objective: This study aimed to determine the effects of a natural diterpenoid, kirenol, on fracture healing in vivo in an experimental rat model of femur fracture and investigate its potential mechanism of action via the Wnt/beta-catenin pathway.