The relationship of periodontal disease severity to serum and GCF substance P levels in diabetics


Ozturk A. , Bilgici B., Odyakmaz S., Konas E.

QUINTESSENCE INTERNATIONAL, vol.43, no.7, pp.587-596, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 7
  • Publication Date: 2012
  • Title of Journal : QUINTESSENCE INTERNATIONAL
  • Page Numbers: pp.587-596
  • Keywords: diabetes, gingival crevicular fluid, neurogenic inflammation, neuropeptides, substance P, GINGIVAL CREVICULAR FLUID, NECROSIS-FACTOR-ALPHA, NEUROGENIC INFLAMMATION, ENZYME-ACTIVITY, ATTACHMENT LOSS, MELLITUS, PLASMA, RAT, NEUROPEPTIDES, MECHANISMS

Abstract

Objective: To compare circulating and gingival crevicular fluid (GCF) substance P concentrations in well- and poorly controlled type 2 diabetic patients with chronic periodontitis. METHOD AND MATERIALS: Forty-five serum and 90 GCF samples were collected from diabetic patients with periodontal disease, and the concentrations of substance P were quantified by radioimmunoassay. RESULTS: Serum substance P levels were higher in the poorly controlled diabetic group than in patients with good glycemic control (P = .01); within the poorly controlled group, patients with severe attachment levels had the highest circulating substance P levels (P = .02). Additionally, the diseased sites showed higher substance P levels than control sites (P = .0016). The GCF substance P concentrations in diseased sites correlated significantly with clinical findings such as Plaque Index (r = 0.51, P = .001) and bleeding on probing (r = 0.35, P = .029). CONCLUSION: Within the limits of this study, our preliminary findings indicate that periodontal inflammation may influence circulating and GCF substance P levels in poorly controlled diabetic subjects. (Quintessence Int 2012;43:587-596)