Peptide-functionalized, -assembled and -loaded nanoparticles in cancer therapy

Dai J., Ashrafizadeh M., Aref A. R., Sethi G., ERTAŞ Y. N.

Drug Discovery Today, cilt.29, sa.7, 2024 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 29 Sayı: 7
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1016/j.drudis.2024.103981
  • Dergi Adı: Drug Discovery Today
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Biotechnology Research Abstracts, Communication Abstracts, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Metadex, Civil Engineering Abstracts
  • Anahtar Kelimeler: drug delivery, nanoparticles, peptides, self-assembled nanoparticles, targeted delivery
  • Erciyes Üniversitesi Adresli: Evet

Özet

The combination of peptides and nanoparticles in cancer therapy has shown synergistic results. Nanoparticle functionalization with peptides can increase their targeting ability towards tumor cells. In some cases, the peptides can develop self-assembled nanoparticles, in combination with drugs, for targeted cancer therapy. The peptides can be loaded into nanoparticles and can be delivered by other drugs for synergistic cancer removal. Multifunctional types of peptide-based nanoparticles, including pH- and redox-sensitive classes, have been introduced in cancer therapy. The tumor microenvironment remolds, and the acceleration of immunotherapy and vaccines can be provided by peptide nanoparticles. Moreover, the bioimaging and labeling of cancers can be mediated by peptide nanoparticles. Therefore, peptides can functionalize nanoparticles in targeted cancer therapy.