Retrospective analysis of adult patients with acute lymphoblastic leukemia undergoing allogeneic hematopoietic cell transplantation: A multicenter experience of daily practice

TEKGUNDUZ E., KAYNAR L., GÖKER H., KAYA A. H., Turak E. E., Eliacik E., ...More

TRANSFUSION AND APHERESIS SCIENCE, vol.54, no.1, pp.41-47, 2016 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.1016/j.transci.2016.01.010
  • Journal Name: TRANSFUSION AND APHERESIS SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.41-47
  • Keywords: Acute lymphoblastic leukemia, ALL, Hematopoietic cell transplantation, Allogeneic, HCT, BONE-MARROW-TRANSPLANTATION, VERSUS-HOST-DISEASE, CLINICAL-TRIALS, THERAPY, SURVIVAL, METAANALYSIS, DIAGNOSIS, REGIMENS, LIVER, INDEX
  • Erciyes University Affiliated: Yes

Abstract

Compared to pediatric age group, the prognosis of adult acute lymphoblastic leukemia (ALL) is still dismal even in patients receiving allogeneic hematopoietic cell transplantation (AHCT). We retrospectively analyzed 205 adults (male: 122; female: 83) with ALL who underwent AHCT. Median age of patients was 28 (18-59). Fifty-two patients had Ph+ ALL. The estimated relapse free and overall survival (OS) of the study cohort at 1, 2 and 3 years were 52.3%/63.9%, 42.9%/49.5% and 39.9%/45.6%, respectively. On multivariate analysis, first complete remission at the time of AHCT, TBI-based conditioning and development of chronic graft-versus-host disease were only factors, which were significantly associated with prolonged OS. (c) 2016 Elsevier Ltd. All rights reserved.