Mesangial proliferative glomerulonephritis in familial Mediterranean fever patient with E148Q mutation: the first case report


EROĞLU E. , KOÇYİĞİT I. , Ateş O. , ÜNAL A. , SİPAHİOĞLU M. H. , AKGÜN H. , ...More

INTERNATIONAL UROLOGY AND NEPHROLOGY, vol.45, no.2, pp.591-594, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 2
  • Publication Date: 2013
  • Doi Number: 10.1007/s11255-012-0124-1
  • Title of Journal : INTERNATIONAL UROLOGY AND NEPHROLOGY
  • Page Numbers: pp.591-594

Abstract

Familial Mediterranean fever (FMF) is an autosomal recessive hereditary disease characterized by recurrent attacks of fever, usually accompanied by sterile polyserositis. Although amyloidosis is the most common renal involvement, non-amyloid renal lesions, such as glomerulonephritis, have been described in patients with FMF. In this report, we present the first case of an FMF patient with heterozygous mutation of E148Q, mesangial proliferative glomerulonephritis, and no amyloidosis. While the association of mutation E148Q with renal involvement is still obscure, colchicine treatment is useful in mesangial proliferative glomerulonephritis with FMF.