Sepsis and Septic Shock; Current Treatment Dilemma and Role of Stem Cell Therapy in Pediatrics


DİNÇ G. , GÖNEN Z. B. , Soltani J., DOĞANAY M.

ARCHIVES OF PEDIATRIC INFECTIOUS DISEASES, vol.9, no.3, 2021 (Journal Indexed in ESCI) identifier identifier

  • Publication Type: Article / Review
  • Volume: 9 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.5812/pedinfect.105301
  • Title of Journal : ARCHIVES OF PEDIATRIC INFECTIOUS DISEASES
  • Keywords: Sepsis, Septic Shock, Mesenchymal Stem Cells, Animal Models, Cell- and Tissue-based Therapy, Treatment, Immunomodulation, MESENCHYMAL STROMAL CELLS, ADIPOSE-TISSUE, MURINE MODELS, EFFICACY, TRIAL, METAANALYSIS, DEFINITIONS, MORTALITY

Abstract

Context: Sepsis's primary therapy consists of antibiotics therapy, supportive therapies, and source control of infection. The failure rate of this approach is about 20-40%. The widespread use of antibiotics has caused multiple drug resistance in primary etiological agents of sepsis in community-acquired and healthcare-associated infections. In the absence of new antibiotic options, alternative treatment modalities seem necessary.