Sepsis and Septic Shock; Current Treatment Dilemma and Role of Stem Cell Therapy in Pediatrics

DİNÇ G., GÖNEN Z. B., Soltani J., DOĞANAY M.

ARCHIVES OF PEDIATRIC INFECTIOUS DISEASES, cilt.9, sa.3, 2021 (ESCI) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 9 Sayı: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.5812/pedinfect.105301
  • Dergi Adı: ARCHIVES OF PEDIATRIC INFECTIOUS DISEASES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, EMBASE
  • Anahtar Kelimeler: Sepsis, Septic Shock, Mesenchymal Stem Cells, Animal Models, Cell- and Tissue-based Therapy, Treatment, Immunomodulation, MESENCHYMAL STROMAL CELLS, ADIPOSE-TISSUE, MURINE MODELS, EFFICACY, TRIAL, METAANALYSIS, DEFINITIONS, MORTALITY
  • Erciyes Üniversitesi Adresli: Evet

Özet

Context: Sepsis's primary therapy consists of antibiotics therapy, supportive therapies, and source control of infection. The failure rate of this approach is about 20-40%. The widespread use of antibiotics has caused multiple drug resistance in primary etiological agents of sepsis in community-acquired and healthcare-associated infections. In the absence of new antibiotic options, alternative treatment modalities seem necessary.