Sepsis and Septic Shock; Current Treatment Dilemma and Role of Stem Cell Therapy in Pediatrics


DİNÇ G., GÖNEN Z. B., Soltani J., DOĞANAY M.

ARCHIVES OF PEDIATRIC INFECTIOUS DISEASES, vol.9, no.3, 2021 (ESCI) identifier identifier

  • Publication Type: Article / Review
  • Volume: 9 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.5812/pedinfect.105301
  • Journal Name: ARCHIVES OF PEDIATRIC INFECTIOUS DISEASES
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, EMBASE
  • Keywords: Sepsis, Septic Shock, Mesenchymal Stem Cells, Animal Models, Cell- and Tissue-based Therapy, Treatment, Immunomodulation, MESENCHYMAL STROMAL CELLS, ADIPOSE-TISSUE, MURINE MODELS, EFFICACY, TRIAL, METAANALYSIS, DEFINITIONS, MORTALITY
  • Erciyes University Affiliated: Yes

Abstract

Context: Sepsis's primary therapy consists of antibiotics therapy, supportive therapies, and source control of infection. The failure rate of this approach is about 20-40%. The widespread use of antibiotics has caused multiple drug resistance in primary etiological agents of sepsis in community-acquired and healthcare-associated infections. In the absence of new antibiotic options, alternative treatment modalities seem necessary.